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Lancet 396:186197 Usmani SZ, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D et al (2022) Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): updated outcomes from a randomised, multicentre, open-label, phase 3 study

Furthermore, acute malnutrition elevates Growth Hormone (GH) and cortisol which promote glycogenolysis, lipolysis and gluconeogenesis, causing wasting of skeletal muscles as amino acids and intermediate metabolites are used up [51]