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Data Animal Data In pregnant rats given daily subcutaneous doses of zoledronic acid of 0.1, 0.2, or 0.4 mg/kg during organogenesis, fetal skeletal, visceral, and external malformations, increases in pre-and post-implantation loss, and decreases in viable fetuses and fetal weight were observed at 0.2 and 0.4 mg/kg/day (equivalent to 2 and 4 times the human 5 mg intravenous dose, based on AUC)

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Armstrong AW, Kircik L, Stein Gold L, Strober B, De Oliveira C, Vaile J, Jou YM, Daamen C, Scharnitz T, Lebwohl M (2025) Deucravacitinib: laboratory parameters across phase 3 plaque psoriasis trials

BPC-157 typically arrives as lyophilized (freeze-dried) powder in vials of 5 mg, 10 mg, or 20 mg requiring reconstitution with bacteriostatic water