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They provide a more holistic picture of the state of cellular metabolism by providing large-scale detection and information on the structural composition and abundance of a broad range of metabolites, although it must be noted it is not possible to detect every metabolite in a system (Amantonico et al., 2010

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14 It has been reported that the percentage of patients with clinically significant disease is less than 20%

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But less obvious is the fact that glutathione also has a crucial role in maintaining this microbiome diversity as well