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An additional consideration is that the IGF-3/IGF-1 ratio may be an important factor determining the level of GH stimulation [3]

TFRC, transferrin receptor

3 The role of ferroptosis in tumor microenvironment 3.1 Overview of ferroptosis in tumor microenvironment Ferroptotic cancer cells exert dual roles within the TME by releasing a variety of signals, which can both activate antitumor immune responses and promote the formation of an immunosuppressive TME