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Oxidative stress is the major pathogenic factor of AIH, and the Keap1-Nrf2 pathway is the main defense mechanism against oxidative stress

Glucose undergoes autoxidation, producing ROS as by-products [173]

Therefore, the study suggests that the mechanism by which tesofensine reduces food intake in obese rats is related to its ability to indirectly stimulate alpha-1 adrenoceptors and dopamine D1 receptors in the brain