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In a study using the HaCaT human keratinocyte cell line, an aqueous solution from Ashwagandha root was found to inhibit the NF-B and MAPK (mitogen-activated protein kinase) pathways by decreasing the expression of proinflammatory cytokines, including interleukin (IL)-8, IL-6, tumour necrosis factor (TNF-), IL-1, and IL-12, and increasing the expression of anti-inflammatory cytokines

Correlation between iron content and dopaminergic degeneration The relationship between iron accumulation in the SNpc and nigrostriatal dopaminergic integrity was explored by correlation analyses in both in vivo human and ex vivo primate cohorts (see Fig