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The DAC version uses a drug affinity complex that extends half-life through albumin binding

[55] It achieves glycemic control primarily through a glucose-dependent mechanism: by binding to GLP-1 receptors on beta cells, it elevates intracellular levels of cyclic AMP (cAMP) and activates protein kinase A (PKA) and related signaling pathways

Bariatric surgery, whilst effective for severe obesity, requires extremely careful consideration in IBD patients and should only be undertaken in specialist centres with expertise in both fields

The goal is identifying and treating the underlying condition causing the elevation

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