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doi: 10.1523/JNEUROSCI.2154-10.2010 70 CaccamoAMaldonadoMABokovAFMajumderSOddoS

In hepatocytes, the genetic defect in the ATP7B gene blocks the uptake of copper into the trans-Golgi network, preventing its biliary excretion and copper loading of apoceruloplasmin

In this regard, as the circadian system is plastic and modifiable, chronomodulation, the strategic alignment of behaviors, treatments, and molecular interventions with the bodys internal clock, offers a compelling and multifaceted strategy to counteract the circadian system decay