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Introduction The functional role of Red Blood Cells (RBCs) is the transport of oxygen from the lungs to the tissues providing the oxygen required by all cells and tissues

Upon activation, Nrf2 translocates to the nucleus, binds specifically to the Antioxidant Response Element (ARE) and induces transcription of downstream genes (Baird and Dinkova-Kostova, 2011) (Figure 2B)

381 Similarly, RTK inhibitors targeting PDGFR (e.g., olaratumab and crenolanib) and c-KIT (avapritinib) show promising BBB penetration but are hindered by resistance mechanisms

Taking higher doses wont fast-track skin whitening but could increase the risk of side effects like bloating, fatigue, or mild allergic reactions in rare cases

Blood 130(10):12091212 Choi R, Lee MN, Kim K, Baek SY, Kim TJ, Hong SN et al (2020) Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohns disease