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On the other hand, ascorbic acid maintained its inhibition of the QS system and decreased pyocyanin production throughout the 24 h incubation, albeit at 1000-fold higher concentration

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315 Astrocytes in AxD show profound alterations in morphology and function, with evidence of abnormal glutamate clearance, substantial cell stress in the form of upregulated expression of heat shock protein, MAPK pathways, JNK and p38 kinases, as well as increased autophagy and proteasomal activity