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This reduction in mitochondrial complex proteins was associated with an increased percentage of neuronal cell apoptosis (Kim et al

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MtDNA mutations and oocyte senescence mtDNA mutations may result from several factors: damage due to environmental factors, ROS-induced damage, polymerase errors during DNA replication, dysfunction of the mtDNA repair system, impaired degradation mechanisms of damaged mtDNA, and age-related accumulation of mutations (as shown in Fig