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For example, miR-21 modulates glycolysis in CD4 + T cells through the PTEN/PI3K/AKT pathway, accelerates the cell cycle, promotes CD4 + T cell polarization toward Th2, and induces fibrogenic cytokine IL-13 expression, which participates in arsenite-mediated fibrosis of the liver [110]

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RA inhibits the development of Th1 cells while promoting Th2 development (humoral Th2 cell response via antigen-presenting cells