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Similar to the IBD and EAE models discussed above, helminthic therapy in the NOD mouse also triggers Th2 skewing due to increases in IL-4 and IL-13 expression, ameliorating Th1-mediated disease (Table 1)

In the first step, enzyme -ECS catalyzes a bond between -COOH of Glu and the -NH 2 group of Cys (Figure 1)

Tauopathy Tau pathology is another major hallmark of AD that is defined by the accumulation of hyperphosphorylated tau protein in neurons, which progress to form intracellular aggregates termed neurofibrillary tangles (NFTs)

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2023-ZDLSF-26) and Guangdong Basic and Applied Basic Research Foundation (No