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While nutritional VC intake demonstrates chemopreventive effects by scavenging carcinogen-induced reactive oxygen species (ROS) and maintaining genomic stability, high-dose intravenous VC acts as a prooxidant to selectively kill tumor cells via ROS-mediated deoxyribonucleic acid (DNA) damage, adenosine triphosphate (ATP) depletion, and HIF-1 degradation

It induces miR-222 , which targets p27Kip1, resulting in CDK2/mTOR activation and the repression of ATGs

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Chronic fatigue syndrome (CFS) also known as Myalgic encephalomyelitis, occurs in diseased individuals, and is defined by an overwhelming sense of tiredness at rest and exhaustion after activities, interfering with daily tasks due to lack of energy (Walsh 2010)