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463 Recently, a research identified that in human corneal epithelial cells exposed to hyperosmotic stress, mtDNA passed through the mPTP pore and was released to the cytoplasm, which activates the cGAS-STING pathway and aggravates inflammation

And its a crucial component of the bodys detox mechanisms

Mitochondrial dysfunction and excessive production of reactive oxygen species promote inflammation and immune dysregulation in SLE

And you can go to ILADs.org for a lot of helpful information, but also for a clinician referral

The number of minor branches of the DPNs was also less in the first 3 weeks after BCNI and gradually increased subsequently