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The pyruvate dehydrogenase complex (PDC) promotes oxidative glucose metabolism, and PDC catalyzes the irreversible decarboxylation of pyruvate to acetyl-CoA, which is inhibited by the action of Pyruvate dehydrogenase kinase (PDHK), which phosphorylates the E1- subunit of Pyruvate Dehydrogenase (PDH) (Stabenow et al., 2022)

[Abstract]2024 Nov 21;22(1):725

However, further studies involving a larger patient cohort and metabolites biologic validation are necessary to enable the implementation of an external test set, which is essential to assess the models reliability

By contrast, such colocalization signal was undetectable in the case of truncated variants of FAT1, including residues 4023-4588 lacking the N-terminal cadherin repeats #28-33 or residues 3790-4588 lacking the cadherin repeats #28-33 and transmembrane sequence (Supplementary Fig

Myseros, S