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Concerns about potential long-term risks associated with chronically elevated GH and IGF-1 levels include possible effects on cancer risk, as IGF-1 can promote cell proliferation and has been associated with increased risk of certain cancers in epidemiological studies, though causal relationships remain debated

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Copper compounds were found to induce MCF-7 cell death through autophagy [54], cell cycle arrest, and inhibition of topoisomerase I [55]