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Additionally, the excessive metabolism of iron can accelerate this process, ultimately leading to ferroptosis in RPECs (169)

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Additionally, as a functional ligand of multiple receptors including LDLR, LDL receptor-related protein (LRP) and heparan sulfate proteoglycans (HSPG), Apo E facilitates the clearance of TRL particles, especially VLDL, VLDL and CM remnant particles, and regulates plasma cholesterol and TG levels 13,57

Incoming cystine is subsequently converted to cysteine, which serves as a substrate for GSH synthesis ( As a member of the glutathione peroxidase family, GPX4 is the first identified core suppressor of ferroptosis ( Figure 2 )