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Topicals work well for mild pigmentation or as maintenance after procedures

The withdrawals/removals included: Placebo Group (11 withdrawals, including 5 due to adverse effects) 4 participants withdrew because their parents lost interest in the study 1 child was removed by the PI due to a change of school 1 participant began behavior medication 1 week into study and was removed by the PI 3 cases of loose stools/ diarrhea (all 3 had gut issues prior to starting, and the continuation of those symptoms caused them to drop out) 1 participant had increased stimming (rubbing face) - history of this, but seemed to worsen 1 participant withdrew due to behavior problems Treatment Group (8 withdrawals, including 3 due to adverse effects) 2 participants were removed from the study because they made changes in their psychiatric medications in the first few weeks of the study

10.1016/S0006-3495(76)85713-X 35 EvansE.RawiczW

Serum CHI3L1 levels were measured using chemiluminescence enzyme-linked immunoassay

These nanocarriers function as protective matrices, isolating sensitive BACs from deleterious external conditions, enhancing their dispersion in aqueous media, and improving their physicochemical stability (16, 17)