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Thymidine analogs have additionally been shown to cause cell senescence through an increase in oxidative stress and induction of mitochondrial dysfunction in human fibroblast cell lines and in subcutaneous adipose tissue from HAART patients ( Protease inhibitors also have the potential to induce oxidative stress, although it is not always clear whether PI induced elevated ROS is produced at the mitochondrial level

304 Fibrotic scar is a common component of MS mature lesions

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