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The first group considered at high risk for severe B12 deficiency had serum B12 287pmol/L and a median methylmalonic acid concentration of 120nmol/L, while the third group was classified as indeterminate and difficult to interpret with an intermediate serum B12 (126287pmol/L)

In the overall cohort, monocyte-to-lymphocyte ratio (MoLR) and neutrophil-to-lymphocyte ratio (NLR) had the best discriminative ability for 3-month outcome (AUC 0.65 and 0.64, respectively), with significant associations maintained in multivariable analysis adjusted for age, sex, onset-to-door delay, acute treatment, large-vessel occlusion, ASPECTS, NIHSS, active cancer, acute CRP, pre-stroke mRS (MoLR: aOR 1.01, 95%CI 1.001.01, p 2 group, all with available thrombi extracted during endovascular thrombectomy (EVT)

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All other evidence is from rodent and in vitro models

Giving folic acid alone to someone with undiagnosed B12 deficiency can precipitate or worsen neurological damage