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Proc Natl Acad Sci 111(25):93199324

Zhigancao decoction significantly reduced MMP-9 (matrix metalloproteinase-9) protein expression in AF rabbits and attenuated myocardial fibrosis, shortened field action potential duration ( CaL action period duration (APD) of rabbit atrial myocytes in the Zhigancao decoction group was significantly prolonged and the atrial ERP was prolonged too ( Dingji Fumai Decoction is a classic Chinese medicine compound with good anti-arrhythmic effect and high safety, but its effective components and specific mechanism of anti-atrial fibrillation are still unclear

Usually 612 sessions for visible improvements

TSPO expression is dependent on disease stage and species differences because of the biological feature in vivo (Tournier et al., 2020)

& Pryma, D