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Auto-immune acanthosis nigricans It is due to the development of antibodies to insulin receptors in autoimmune diseases such as systemic lupus erythematosus.[9] Acral acanthosis nigricans (acralacanthotic anomaly) It occurs in otherwise healthy patients

Cell (2016) 167:829842.e13.10.1016/j.cell.2016.09.031 35 MurphyMP

Amongst the established chemotherapeutic agents, metallodrugs have been extensively used for cancer therapy where they offer versatile electronic and unique structural features [3,4,5]

ShengXZhaoJLiMXuYZhouYXuJet al

[268] It is envisaged that the composition of the invention might comprise, in addition to the polypeptide of the invention defined herein, further biologically active agents, depending on the intended use of the composition