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This complexity suggests that combinatorial interventions targeting multiple death pathway nodes synergistically may more effectively disrupt the death-resistant barriers of leukemia cells, thereby opening multidimensional attack pathways to overcome therapeutic bottlenecks caused by AML clonal evolution and microenvironmental sheltering (18)

doi: 10.1016/S0021-9258(17)30910-9 59

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Based on the low level of serum vitamin B12 coexisting with unexplained proteinuria, the diagnosis of IGS was favored

This is particularly important for essential and abundant proteins whose overoxidation would lead to loss of cell viability and requires new protein synthesis to replace inactivated proteins