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A population-based study in 3,884 elderly men and women with depressive disorders found that those with vitamin B 12 deficiency were almost 70% more likely to experience depression than those with normal vitamin B 12 status (98)

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In vitro studies revealed that AOD9604 enhances the differentiation of adipose-derived mesenchymal stem cells into bone, stimulates the production of proteoglycans and collagen in chondrocytes, and promotes myoblast differentiation into muscle cells

[129] [130] Later steps, especially the incorporation of the additional methyl groups of its structure, were investigated using 13 C methyl-labelled S-adenosyl methionine