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Male rats with PTSD-like behaviors showed elevated p -cresol (a neurotoxic metabolite linked to overgrowth of Ruminococcaceae and Lachnospiraceae ) in prefrontal cortex, leading to dopaminergic dysfunction with increased DA, increased dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and significantly elevated DA D3 receptor expression compared to controls (Laudani et al., 2023)

Matrix metalloproteinase-driven epithelial-mesenchymal transition: implications in health and disease

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In Table 1 we summarize the studies using pharmacological approaches in iPSC-derived neurons of relevance for SCZ research