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Researchers have found that TRPM3 channels are strongly inhibited by peripheral mu-opioid receptor activation.[ref] This may be the connection as to why LDN helps some people with ME/CFS.[ref open access, worth reading] A 2024 study explains that TRPM3 dysfunction in natural killer cells may be at the root of the ineffective pathogen clearance seen in some ME/CFS individuals

31 Topical antiseptics, topical antibiotics, oral antibiotics, and systemic isotretinoin can be used for treatment