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Subsequently, on days 21 to 23, the pulmonary drug delivery device was used to directly intratracheally spray BUD, LNPs, and BUD-LNPs into the airways of mice (Figure 6a)

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With reference to the precision medicine research paradigmdiscovery-validation-translation, we systematically describe omics technologies (genomics transcriptomics metabolomics proteomics network medicine) and AI technologies (diagnosis treatment management workflow optimization prevention), formulating a comprehensive pipeline that spans from technological foundations to clinical applications