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Description

2020;117:F3XL Modig K

Briefly, we quantified GPs using the label-free, intensity-based absolute quantification (iBAQ) method and then normalized to final quantificational value (FOT) defined as the iBAQ value of an individual protein divided by the total iBAQ values of all identified proteins within one experiment

We hypothesize that this mutation could promote a more stable interaction of KEAP1 with Cul3, increasing NRF2 degradation and explaining the lower levels in this cell line