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For example, IDO1 mediated kynurenine signaling activates NF-B in endothelial cells, promoting adhesion molecule expression (VCAM-1, ICAM-1) and monocyte recruitment, associating Trp catabolism directly to endothelial dysfunction and atherogenesis as confirmed in both murine and human studies where elevated kynurenine levels correlate with carotid intimamedia thickness and endothelial oxidative stress 51,134

Effects of selenium source on measures of selenium status and immune function in horses

doi: 10.1029/2022GL100586 126 WrightR

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