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4 Future perspectives The endocannabinoid system has been the focus of extensive research due to its promising therapeutic potential, with studies conducted in various fields, including psychiatry, inflammatory diseases and cancer ( To better assess the interaction potential of existing or novel cannabinoids and other compounds affecting endocannabinoid system activity, it would be advisable to incorporate additional tests beyond the standard in vitro inhibition studies currently required by the EMA and FDA during preclinical drug evaluation

Separately, ghrelin, produced primarily in the stomach and hypothalamus, binds ghrelin receptors on pituitary somatotrophs and amplifies GH release through a distinct intracellular pathway

doi: 10.1039/c7fo00220c 99