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Description

Liu Y, Austin E, Xiang J, et al

We showed that restoring the inhibition of the CUL5 second messenger degradation pathways with neddylation activating enzyme inhibitor (NAEi) could enhance/restore Treg function and re-establish normal immune tolerance

Cham: Springer International Publishing (2023)

Additionally, IGF-1 may be associated with a low oxygen microenvironment since IGF-1 stimulates the production of hypoxia inducible factor-1 (HIF-1) protein through the PI3K/mTOR and MEK/ERK pathways [2022]

Additional Information Background GSH-Px is one of the main enzymes that catalyze the oxidation of reduced glutathione (GSH) in the glutathione redox cycle