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55,57 These injured or profibrotic tubular cells recruit macrophages, lymphocytes, and fibroblasts, promoting tissue fibrosis and leading to irreversible kidney damage

Beta-catenin ( Ctnnb1 ) plays a role in macrophage lineage differentiation [123] and myeloid -catenin expression modulates macrophage inflammatory responses[124]

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While cGAS signals via stimulator of interferon genes (STING) to induce predominantly IFN I, TLRs signal via the adaptor protein myeloid differentiation primary response (MyD)88 and the transcription factor NF-B to activate the expression of IL-1, IL-6 and IL-18 and of AIM2, NLRP3 and other elements of the inflammasome