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The two most common are: C677T Variant (rs1801133): This variation can reduce enzyme activity by up to 70% in people with two copies of the mutation

Thus, in a randomized clinical trial conducted in selenium-sufficient GD patients treated with methimazole, no beneficial effect of Se on the short-term control of thyroid hyperfunction was observed (82)

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In addition to endogenous antioxidant defenses, exogenous antioxidants found in various foods, such as polyphenols, vitamin C, vitamin E and carotenoids, can also help neutralize ROS and support cellular health [19]

Our findings revealed that elevated GLO-1 expression correlated with poorer OS in ACC, MESO, and SARC, but no such association was observed in KIRC or LIHC ( Figure 2A )