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Its analgesic effects appear to be primarily mediated through the activation of opioid receptors and the L-arginine/NO/cGMP signaling pathway

J Nutr 1983;113:136373

Review articles summarizing preclinical BPC-157 literature describe how the peptide has been investigated in models examining angiogenesis-linked bone remodeling and connective tissue regeneration, often in the context of nitric oxideassociated vascular signaling pathways [2]