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Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations, we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD+ salvage cycle

68 It depletes M2-TAMs, 69,70 disrupts TGF- signaling, 71 and promotes chemokines such as CXCL1, 72 leading to increased CD8 and NK cell infiltration and reduced Tregs and MDSCs