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Contact your GP or bariatric team promptly if you experience: Numbness that is worsening rather than gradually improving Numbness accompanied by significant leg pain, swelling, warmth, or redness (which may suggest DVT seek same-day assessment) Weakness in the leg or difficulty walking Numbness that extends beyond the thigh to involve the lower leg or foot Bladder or bowel changes alongside leg symptoms, or saddle anaesthesia (numbness in the groin, inner thighs, or buttocks), which may indicate cauda equina syndrome seek emergency assessment immediately Symptoms that begin or worsen several months after surgery, which may suggest a nutritional cause Call 999 or go to A&E immediately if you develop sudden breathlessness, pleuritic chest pain (sharp pain that worsens on breathing), or coughing up blood these may be signs of a pulmonary embolism (PE) , which is a medical emergency

86 It has been observed in animal models that sustained glucocorticoid stimulation can increase the excitability of glutamatergic neurons and simultaneously decrease the number and plasticity of astrocytes, in addition to decreasing neuronal dendrite connectivity in the hippocampus and frontal cortex, leading to depression

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Caspase-3 is a key enzyme in the apoptosis pathway

It is through that boundary-pushing, done thoughtfully, that the field will mature