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The meta-analysis, which pooled data across multiple studies using a random-effects model, found that lower B12 was significantly associated with metabolic syndrome markers including elevated blood pressure, elevated fasting glucose, and abnormal lipid profiles

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This inertness is maintained by the highly acidic C-terminal tail, which plays a crucial role in preserving Syn in a soluble state 5,7,8

It is hoped that this review will convince scientists and clinicians to look past paracellular permeability to other mechanisms by which endotoxin is taken into the body in the hope that interventions can be devised that prevent endotoxin uptake and that mechanistic interpretations of processes that increased paracellular permeability can be made