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European journal of medical research, 13 (2), 7378

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More water spreads the dose across more units for finer control

Grids were blotted for 4.0 s under 100% humidity at 4 C before being plunged into the liquid ethane using a Mark IV Vitrobot (FEI)

additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable