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Most trials assess main effects independently or in factorial designs without statistical modeling for interaction effects

The peptide's effects on neurogenesis and neural progenitor cells further contribute to its regenerative potential

For example, Ca V 3.2 activity is enhanced in diabetes through the glycosylation of extracellular arginine residues resulting in DRG neuron hyperexcitability 116

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People with certain medical conditions should not use senna, including: intestinal obstruction ulcerative colitis Crohns disease appendicitis dehydration diarrhea kidney problems heart problems previous allergic reaction to senna Nobody under the age of 18 should take senna without a doctors recommendation