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In addition to regulating genes and RNAs, targeted protein degradation has become a hot research topic due to its advantages of direct and fast action

Furthermore, we examine experimental in vitro and in vivo data regarding the application of non-canonical nucleosides in cell and animal models and evaluate the future prospects of modified mRNA-based therapies

10.1016/j.molmet.2019.06.026 81

Sung Hee Um et al

Furthermore, the inhibition of SAM production in tumor cells by deleting methionine adenosyltransferase II alpha ameliorates the CD8 + T cell exhaustion phenotype and delays tumor growth [260]