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Factors contributing to the increased susceptibility of OLs to oxidative stress include the high intracellular iron content of the cells and relatively low levels of endogenous antioxidant proteins, which are lower in OPCs compared with mature OLs [14,15,23,24]

In line with this, another study found that valproic acid (VPA), an HDAC inhibitor, induced TGF-mediated EndMT in endothelial cells [100]

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FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo