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MA: Writing original draft, Writing review & editing, Methodology

Furthermore, US11 a tegument viral protein that is expressed late in the replication cycle of HSV-1, has been reported to interact directly with PKR and inhibit subsequent eIF2 phosphorylation (Figure 2B

Its activity is increased in SCD plasma, but its source remains to be clearly identified [143]

Although previous studies have extensively documented the regulatory function of abnormal lactate metabolism in different cancers, the abnormal metabolism of amino acids in tumors, particularly branched chain amino acids (BCAA), remains a promising avenue that needs further in-depth investigation in future research

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