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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

FernandesRCamposJSerraMFidalgoJAlmeidaHCasasAet al

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One method that has enjoyed preliminary success in reversing the aberrant immune response in type 1 diabetes is the presentation of the proinsulin autoantigen without the costimulatory factors needed to activate cytotoxic T cells

however, its concentration at physiological pH is very low compared to the concentration of superoxide (at pH = 7, ratio O 2 : HOO = 100: 1)