cofactor for enzyme glutathione peroxidase The family: Discoveries and mechanism Glutathione Peroxidase-1 in Health and

Despite promising preliminary findings, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses

Elevated intracellular iron levels facilitate the generation of ROS through Fenton chemistry, subsequently initiating lipid peroxidation reactions (20)

Lactic acid production by tumor cells, as a byproduct of aerobic or anaerobic glycolysis, has also been shown to play a vital role in the M2-like polarization of TAMs, which is mediated by HIF- 1 (294)

S2 of the ESM

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