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Koutsoudakis, G

The histone methyltransferase NSD1 has been identified as having potential therapeutic value by upregulating the H3K36me2 modification, thereby activating the expression of the transcription factor SOX9, which subsequently downregulates the key enzyme for ferroptosis, ACSL4, thus attenuating chondrocyte ferroptosis (170)

In addition, we observed a significant elevation of succinyladenosine in the MMA group following age adjustment, suggesting altered purine metabolism and mitochondrial energy homeostasis in MMA