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Six months after treatment, memory scores improved significantly, cerebrospinal fluid protein levels decreased in patients who underwent repeat lumbar puncture, and brain perfusion improved on SPECT imaging in the patients who were re-evaluated

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Another study introduced an MMP-clearable sequence at both ends of a bioactive peptide while additionally incorporating thiol-functionalized crosslinkers at each end, thus developing C-IPESLRAG-bioactive peptide-IPESLRAG-C-G to enable conjugation with norbornene-functionalized PEG [344]

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Each of the digested samples was made up to 20 mL with double distilled water and assayed for the presence of Iron (Fe), Manganese (Mn), Selenium (Se) and Copper (Cu) using VARIAN AA 240FS-Atomic Absorption Spectrometer in an acetylene-air flame (FLUKA ANALYTICAL, Sigma-Aldrich Chemie GmbH)

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