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This can serve as a therapeutic target against aging and age-related disorders.70 For example, rapamycin, an mTOR inhibitor restores autophagy and delays senescence-related diseases.71,72 Similarly, spermidine induces autophagy and improves cellular renewal, thus promoting longevity.73 Regulation of Oxidative Stress and DNA Damage Response: Oxidative stress and DNA damage are major drivers of senescence

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(July 2024)

Concentrations decline with age

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