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Systems biology is an integrative research approach that aims to uncover the underlying complexity of biological processes by analyzing biological networks and pathways systematically

& Salustri, A

In albino rats treated first with pyrazole, an inhibitor of ADH, injected (ip) with a solution of acetaldehyde in saline (200 mg/kg body weight per day) for 10 days, and then sacrificed 30 min after receiving the last injection, acetaldehyde was detected in the brain, liver, and blood (Prasanna & Ramakrishnan, 1984b, 1987)

The main limitation is the technique of choice and its particularities per study, as well as some discrepancies in the fine details of elastase inhibition assays