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Its homolog SPACA4, functionally analogous to the teleost fertilization factor Bouncer , acts as a critical sperm protein required for zona pellucida penetration during mammalian fertilization

[43] [45] The relatively good scavenging activity of LA toward hypochlorous acid (a bactericidal produced by neutrophils that may produce inflammation and tissue damage) is due to the strained conformation of the 5-membered dithiolane ring, which is lost upon reduction to DHLA